Temperature-Sensitive Live-Attenuated Canine Influenza Virus H3N8 Vaccine

Temperature-Sensitive Live-Attenuated Canine Influenza Virus H3N8 Vaccine.

Canine influenza is a respiratory disease of dogs caused by canine influenza virus (CIV). CIV subtypes responsible for influenza in dogs include H3N8, which originated from the transfer of H3N8 equine influenza virus to dogs; and the H3N2 CIV, which is an avian-origin virus that adapted to infect dogs. Influenza infections are most effectively prevented through vaccination to reduce transmissio...

Elastase-Dependant Live Attenuated Swine Influenza Virus Vaccine in Pigs

Swine influenza (SI) is an acute, highly contagious, respiratory disease of swine caused by influenza A viruses. In addition, SI infections possess significant human public health concerns as they may serve as intermediate host for the generation of new pandemic viruses. Vaccination is still the primary method for the prevention and control of SI. Currently, commercially available vaccines agai...

Small-particle aerosolization of live attenuated influenza vaccine virus.

To the Editor—In their recent study, Bischoff et al [1] exposed subjects to a small-particle aerosol of commercially available live attenuated influenza vaccine (LAIV; MedImmune LLC, Gai-thersburg, MD). LAIV was used as a proxy for wild-type influenza to evaluate the protection provided by N95 respirators, surgical masks, and eye protection. Although the study addresses the important question o...

Development of an Attenuated Live Virus Vaccine against Sheep Pox

Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach.

Type B influenza viruses can cause substantial morbidity and mortality in the population, and vaccination remains by far the best means of protection against infections with these viruses. Here, we report the construction of mutant influenza B viruses for potential use as improved live-virus vaccine candidates. Employing reverse genetics, we altered the NS1 gene, which encodes a type I interfer...